A unifying model of glucotoxicity in human renal proximal tubular epithelial cells and the effect of the SGLT2 inhibitor dapagliflozin.

Theodoros EleftheriadisGeorgios PissasKonstantina TsogkaEvdokia NikolaouVassilios LiakopoulosIoannis Stefanidis

Published in: International urology and nephrology (2020)

Our results support a unifying model for glucotoxicity in RPTECs. Dapagliflozin by decreasing the elevated glucose influx into the RPTECs under high glucose conditions ameliorates glucotoxicity.

Keyphrases

high glucose
endothelial cells
mouse model
type diabetes
induced pluripotent stem cells
pluripotent stem cells