The protective gene dose effect of the APOE ε2 allele on gray matter volume in cognitively unimpaired individuals.

Gemma Salvadó Daniel Ferreira Grégory Operto Irene Cumplido-Mayoral Eider M Arenaza-Urquijo Raffaele Cacciaglia Juan Domingo Gispert Natàlia Vilor-Tejedor Carolina Minguillón Colin Groot Wiesje Maria van der Flier Frederik Barkhof Philip Scheltens Rik OssenkoppeleSilke KernAnna ZettergrenIngmar SkoogJakub HortErik Stomrud Danielle van Westen Oskar Hansson José Luis L Molinuevo Lars-Olof Wahlund Erik Westman Juan-Domingo Gispertnull null

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2021)

In addition to the known resistance against amyloid-β deposition, the larger GM volumes in key brain regions may confer APOE ε2 homozygotes additional protection against AD-related cognitive decline.

Keyphrases

cognitive decline
mild cognitive impairment
resting state
white matter
copy number
genome wide
functional connectivity
genome wide identification
type diabetes
multiple sclerosis
cerebral ischemia
dna methylation
metabolic syndrome