Hypermethylation of the FOXP3 gene regulates Tregs immunodysregulation in chronic idiopathic thrombocytopenic purpura.

Zengsheng WangTao LangYan LiXiaoyan ZhangMuhubair AbdurMin Mao

Published in: Allergologia et immunopathologia (2024)

The number of Treg cells in CITP patients decreased, and the hypermethylation of FOXP3 promoter led to reduction of its expression in Treg cells, thus affecting the immune functioning of Treg cells.

Keyphrases

induced apoptosis
cell cycle arrest
regulatory t cells
endoplasmic reticulum stress
gene expression
oxidative stress
poor prognosis
cell death
immune response
cell proliferation
patient reported outcomes
genome wide
genome wide analysis