ATP citrate lyase (ACLY)-dependent immunometabolism in mucosal T cells drives experimental colitis in vivo.
Anja Schulz-KuhntKatharina RühleAsal JavidmehrMichael DöbröntiJana BiwankSelina KnittelPeter NeidlingerJannik LeupoldLi-Juan LiuMark DeddenRegina Verena TaudteArne GessnerMartin F FrommDirk MielenzLucas KreissMaximilian J WaldnerSebastian SchürmannOliver FriedrichBarbara DietelRocío López-PosadasChristina Plattnernull nullSebastian ZundlerChristoph BeckerGisela FeltenMarkus Friedrich NeurathImke AtreyaPublished in: Gut (2024)
ACLY controls mucosal T cell immunometabolism and experimental colitis. Therapeutic modulation of ACLY expression in T cells emerges as a novel strategy to promote the resolution of intestinal inflammation.