Following hearts, one cell at a time: recent applications of single-cell RNA sequencing to the understanding of heart disease.
Matthew Ackers-JohnsonWilson Lek Wen TanRoger Sik Yin FooPublished in: Nature communications (2018)
The mammalian heart contains heterogeneous cell types contributing to pathological changes in cardiac disease. In this Comment, we explore how single-cell transcriptomic approaches are unveiling intricate cellular mechanisms and gene co-expression networks that regulate the workings, and failings, of the heart.