Multiomics characterization of methicillin-resistant Staphylococcus aureus (MRSA) isolates with heterogeneous intermediate resistance to vancomycin (hVISA) in Latin America.
Betsy E CastroRafael RiosLina P CarvajalMónica L VargasMónica P CalaLizeth LeónBlake M HansonAn Q DinhOscar Ortega-RecaldeCarlos SeasJose M MunitaCesar A AriasSandra RinconJinnethe ReyesLorena DiazPublished in: The Journal of antimicrobial chemotherapy (2022)
Our results show that the mechanism of hVISA involves major changes in regulatory systems, expression of virulence factors and reduction in glycolysis via TCA cycle. This work contributes to the understanding of the development of this complex resistance mechanism in regional strains.