Serum Lipidomic Screen Identifies Key Metabolites, Pathways, and Disease Classifiers in Crohn's Disease.

Romain Ferru-ClémentGabrielle BoucherAnik ForestBertrand BouchardAlain BittonSylvie LesagePhil SchummMark LazarevSteve BrantRichard H DuerrDermot P B McGovernMark SilverbergJudy H Chonull nullAshwin AnanthakrishnanRamnik J XavierJohn D RiouxChristine Des Rosiers

Published in: Inflammatory bowel diseases (2023)

Untargeted lipidomic analyses uncovered perturbations in the circulating human CD lipidome, likely resulting from multiple pathogenic mechanisms. Models using as few as 5 biomarkers had strong disease classifier characteristics, supporting their potential use in diagnosis or prognosis.

Keyphrases

endothelial cells
gene expression
ms ms
genome wide
climate change
human health
simultaneous determination
pluripotent stem cells
solid phase extraction