The nuclear export protein exportin-1 in solid malignant tumours: From biology to clinical trials.

Published in: Clinical and translational medicine (2024)

Exportin-1 (XPO1) plays a critical role in mediating nucleocytoplasmic transport and cell cycle. XPO1 dysfunction promotes tumourigenesis and drug resistance within solid tumours. The therapeutic potential and ongoing researches on XPO1 inhibitors in the treatment of solid tumours. Additional researches are essential to address safety concerns and identify biomarkers for predicting patient response to XPO1 inhibitors.

Keyphrases

cell cycle
clinical trial
cell proliferation
oxidative stress
randomized controlled trial
protein protein
amino acid
small molecule
open label
smoking cessation