A frog peptide provides new strategies for the intervention against skin wound healing.
Chao LiZhe FuTao JinYixiang LiuNaixin LiuSaige YinZhuo WangYubing HuangYinglei WangYingxuan ZhangJiayi LiYutong WuLi HeJing TangYing WangMeifeng YangPublished in: Cellular & molecular biology letters (2023)
OA-RD17 exhibited promising therapeutic effects on mice (full-thickness, deep second-degree burns), and ex vivo skin wounds in diabetic patients by regulating macrophages proliferation, migration, and polarization (MAPK, NF-κB), and keratinocytes proliferation and migration (TLR4/MAPK/miR-632/Wnt/β-catenin molecular axis). Moreover, miR-632 also activated Wnt/β-catenin to promote full-thickness skin wound healing in rats. Notably, our results indicate that OA-RD17 and miR-632 are promising pro-healing drug candidates.
Keyphrases
- wound healing
- cell proliferation
- pi k akt
- signaling pathway
- long non coding rna
- oxidative stress
- epithelial mesenchymal transition
- long noncoding rna
- randomized controlled trial
- optical coherence tomography
- stem cells
- toll like receptor
- inflammatory response
- knee osteoarthritis
- nuclear factor
- type diabetes
- lps induced
- adverse drug
- wild type