A Randomized, Double-Blind, Placebo-Controlled Multicenter Efficacy and Safety Study of Methotrexate to Increase Response Rates in Patients With Uncontrolled Gout Receiving Pegloticase: 12-Month Findings.

John K BotsonKenneth SaagJeff PetersonKatie ObermeyerYan XinBrian LaMoreaux Lissa Padnick-SilverSupra VermaSuneet GrewalAmar MajjhooJohn R P TesserMichael E Weinblatt

Published in: ACR open rheumatology (2023)

Twelve-month MIRROR RCT data further support MTX cotherapy with pegloticase. Tophi resolution continued to increase through week 52, suggesting continued therapeutic benefit beyond month 6 for a favorable treatment effect.

Keyphrases

placebo controlled
double blind
clinical trial
phase ii
phase iii
study protocol
phase ii study
electronic health record
randomized controlled trial
big data
squamous cell carcinoma
metabolic syndrome
deep learning
machine learning
combination therapy
radiation therapy