An update on the implications of cyclin D1 in melanomas.
Lucia González-RuizMiguel Ángel González-MolesIsabel González-RuizIsabel Ruiz-ÁvilaÁngela AyénPablo Ramos-GarcíaPublished in: Pigment cell & melanoma research (2020)
Cyclin D1 is a protein encoded by the CCND1 gene, located on 11q13 chromosome, which is a key component of the physiological regulation of the cell cycle. CCND1/cyclin D1 is upregulated in several types of human tumors including melanoma and is currently classified as an oncogene that promotes uncontrolled cell proliferation. Despite the demonstrated importance of CCND1/cyclin D1 as a central oncogene in several types of human tumors, its knowledge in melanoma is still limited. This review examines data published on upregulation of the CCND1 gene and cyclin D1 protein in the melanoma setting, focusing on the pathways and molecular mechanisms involved in the activation of the gene and on the clinical and therapeutic implications.
Keyphrases
- cell cycle
- cell proliferation
- copy number
- endothelial cells
- genome wide
- genome wide identification
- healthcare
- skin cancer
- induced pluripotent stem cells
- pi k akt
- signaling pathway
- electronic health record
- systematic review
- protein protein
- amino acid
- randomized controlled trial
- small molecule
- transcription factor
- big data
- deep learning
- data analysis
- basal cell carcinoma