Login / Signup

Gold-catalyzed benzannulations of 2-alkenylindoles with alkynes: a protecting-group-free regioselective approach to carbazoles.

Pathan Mosim AminWeilin WangChao WangJunrui ZhouYouliang Wang
Published in: Chemical communications (Cambridge, England) (2024)
A gold(I)-catalyzed protecting-group-free benzannulation approach to functionalized NH-carbazoles was accomplished via the hydroarylation of alkynes with 2-alkenylindoles. A broad spectrum of terminal and internal alkynes and 2-alkenylindoles successfully participated in this annulation reaction. The protocol efficiently enabled the formation of substituted NH-carbazoles with moderate to specific regioselectivities. The synthetic utility of this protocol was demonstrated by a variety of post-functionalizations.
Keyphrases
  • room temperature
  • randomized controlled trial
  • ionic liquid
  • silver nanoparticles
  • molecular docking
  • quantum dots
  • perovskite solar cells
  • mass spectrometry
  • electron transfer