Durable anti-Vi IgG and IgA antibody responses in 15-month-old children vaccinated with typhoid conjugate vaccine in Burkina Faso.

Alphonse OuedraogoAmidou DiarraIssa NébiéNouhoun BarryJean Moise KaboreAlfred B TionoShrimati DattaYuanyuan LiangIfayet MayoJennifer OshinskyJ Kathleen TracyTsion GirmayMarcela PasettiLeslie P JamkaKathleen M NeuzilSodiomon B SirimaMatthew B Laurens

Published in: Journal of the Pediatric Infectious Diseases Society (2023)

We assessed anti-Vi IgG/IgA responses to typhoid conjugate vaccine (TCV) in children enrolled in a double-blind randomized, controlled, phase 2 trial in Burkina Faso. Anti-Vi IgG seroconversion and anti-Vi IgA titers were higher in TCV than control recipients at 30-35 months post-vaccination. TCV induces durable immunity in Burkinabe children vaccinated at 15-months.

Keyphrases

young adults
randomized controlled trial
drug delivery
phase iii
phase ii
placebo controlled