The Pathogenic Aspects of Human Parvovirus B19 NS1 Protein in Chronic and Inflammatory Diseases.

Sedigheh JalaliAli FarhadiGholamreza Rafiei DehbidiShirin FarjadianSedigheh SharifzadehReza RanjbaranNoorossadat SeyyediSepide NamdariAbbas Behzad Behbahani

Published in: Interdisciplinary perspectives on infectious diseases (2022)

Overall, our results indicated that proinflammatory cytokine levels had increased following the expression of hPVB19 NS1 in HEK-293T cells, consistent with a role for NS1 expression facilitating the upregulation of inflammatory reactions. Therefore, hPVB19 NS1 function may play a role in the progression of some chronic and inflammatory diseases.

Keyphrases

poor prognosis
dengue virus
oxidative stress
binding protein
endothelial cells
zika virus
long non coding rna
cell proliferation
protein protein
drug induced