DNMT1 regulates hypermethylation and silences hsa_circ_401351 in hydroquinone-induced malignant TK6 cells.

Yali HanJinxue MengXiaoxuan LingZhijie PanHaiqiao ZhangBohuan ZhongShi ChenJing PangYuliang MaJialong ChenLinhua Liu

Published in: Environmental toxicology (2023)

Overall, our research showed that elevated DNMT1 expression in HQ-TK6 cells increased methylation levels and decreased expression of the hsa_circ_401351 promoter region, limiting its ability to suppress HQ-TK6 cell growth and enhance apoptosis.

Keyphrases

cell cycle arrest
dna methylation
induced apoptosis
poor prognosis
endoplasmic reticulum stress
oxidative stress
pi k akt
gene expression
genome wide
signaling pathway
binding protein
high glucose
endothelial cells