Acute Cytokine Response During Breast Cancer Surgery: Potential Role of Dexamethasone and Lidocaine and Relationship with Postoperative Pain and Complications - Analysis of Three Pooled Pilot Randomized Controlled Trials.
Sandra A S Van den HeuvelSelina E I van der WalEwald Maria BronkhorstMichiel C WarléMay RondayJudith PlatNens van AlfenLeo A B JoostenJos G C LerouKris C P VissersMonique A H SteegersPublished in: Journal of pain research (2020)
Dexamethasone modulated the perioperative cytokine response into an anti-inflammatory direction. An overall lidocaine effect was not found. Patients with higher pain scores suffered from more 30-day PIRCs. Cytokine levels were not associated with pain or more postoperative complications, even not with PIRC. Larger studies in breast cancer surgery are needed to confirm these explorative results.
Keyphrases
- postoperative pain
- minimally invasive
- chronic pain
- coronary artery bypass
- pain management
- randomized controlled trial
- anti inflammatory
- neuropathic pain
- low dose
- high dose
- liver failure
- surgical site infection
- risk factors
- study protocol
- respiratory failure
- clinical trial
- spinal cord
- drug induced
- acute coronary syndrome
- atrial fibrillation
- open label
- breast cancer risk
- meta analyses