Brain structural correlates of cognitive-attentional syndrome - a Voxel-Based Morphometry Study.
Joachim KowalskiMarek WypychArtur MarchewkaMałgorzata DraganPublished in: Brain imaging and behavior (2022)
Cognitive-attentional syndrome (CAS) is in the self-regulatory executive function model a set of cognitive and behavioural strategies aimed at regulating cognition and emotion originating from maladaptive metacognitive beliefs. Investigating the brain structure of people with high levels of CAS enables a better understanding of the syndrome and bridging between the metacognitive model of psychopathology and previous results on structural abnormalities in various psychological disorders. Participants with high (n=40) and low levels of CAS (n=44) underwent structural Magnetic Resonance Imaging session. Voxel-Based Morphometry analytical approach was used to compute grey matter volume (GMV) differences between the groups. The group with a high level of CAS had lower GMV in the dorsal part of the anterior cingulate cortex. Our results are in line with the self-regulatory executive function model of psychopathology, showing a link between CAS and lowered GMV in the brain region associated with the regulation of cognition and emotion. They are also in agreement with meta-analytical results on structural correlates of various psychological disorders.
Keyphrases
- crispr cas
- genome editing
- white matter
- resting state
- functional connectivity
- magnetic resonance imaging
- case report
- autism spectrum disorder
- transcription factor
- depressive symptoms
- multiple sclerosis
- working memory
- spinal cord
- computed tomography
- liquid chromatography
- anorexia nervosa
- high intensity
- spinal cord injury
- magnetic resonance
- blood brain barrier