An assembly of TROP2-mediated signaling events.
Shubham Sukerndeo UpadhyayDevasahayam Arokiar Balaya RexSakshi Sanjay ParateShobha DagamajaluThottethodi Subrahmanya Keshava PrasadRohan ShettyRajesh RajuPublished in: Journal of cell communication and signaling (2023)
Trophoblast cell surface antigen 2 (TROP2) is a calcium-transducing transmembrane protein mainly involved in embryo development. The aberrant expression of TROP2 is observed in numerous cancers, including triple-negative breast cancer, gastric, colorectal, pancreatic, squamous cell carcinoma of the oral cavity, and prostate cancers. The main signaling pathways mediated by TROP2 are calcium signaling, PI3K/AKT, JAK/STAT, MAPKs, and β-catenin signaling. However, collective information about the TROP2-mediated signaling pathway is not available for visualization or analysis. In this study, we constructed a TROP2 signaling map with respect to its role in different cancers. The data curation was done manually by following the NetPath annotation criteria. The described map consists of different molecular events, including 8 activation/inhibition, 16 enzyme catalysis, 19 gene regulations, 12 molecular associations, 39 induced-protein expressions, and 2 protein translocation. The data of the TROP2 pathway map is made freely accessible through the WikiPathways Database ( https://www.wikipathways.org/index.php/Pathway:WP5300 ). Development of TROP2 signaling pathway map.
Keyphrases
- signaling pathway
- pi k akt
- squamous cell carcinoma
- cell proliferation
- binding protein
- epithelial mesenchymal transition
- cell cycle arrest
- cell surface
- poor prognosis
- induced apoptosis
- electronic health record
- amino acid
- oxidative stress
- high density
- emergency department
- protein protein
- single molecule
- machine learning
- adverse drug
- copy number
- high glucose
- cell death
- young adults
- small molecule
- lymph node metastasis
- wastewater treatment
- endoplasmic reticulum stress
- rna seq