Early distribution of 18 F-labeled AAV9 vectors in the cerebrospinal fluid after intracerebroventricular or intracisternal magna infusion in non-human primates.
Shinichi KumagaiTakeshi NakajimaKuniko ShimazakiTakeharu KakiuchiNorihiro HaradaHiroyuki OhbaYoshiyuki OnukiNaomi TakinoMika ItoMakoto SatoSachie NakamuraHitoshi OsakaTakanori YamagataKensuke KawaiShin-Ichi MuramatsuPublished in: The journal of gene medicine (2022)
For gene therapy that primarily targets the cervical spinal cord and brainstem, such as amyotrophic lateral sclerosis, cisterna magna infusion would be a feasible and effective administration method.