Therapeutic targeting of LIF overcomes macrophage mediated immunosuppression of the local tumor microenvironment.
Robin HallettEster Bonfill-TeixidorRaffaella IurlaroAlexandra AriasSwetha RamanPeter E BaylissOlga EgorovaAlmudena Neva-AlejoA J Robert McGrayEsther LauAlexandre BoschMelissa BeilschmidtDorothea MaetzelJohan FranssonIsabel Huber-RuanoJudit AnidoJean-Philippe JulienPatricia A GiblinJoan SeoanePublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Overall, our findings highlight LIF as a therapeutic target for cancer immunotherapy.