Effect of weight loss on knee joint synovitis over 48 months and mediation by subcutaneous fat around the knee: data from the Osteoarthritis Initiative.
Maximilian T LöfflerChotigar NgarmsrikamPaula GieslerGabby B JosephZehra AkkayaJohn A LynchNancy E LaneMichael NevittCharles E McCullochThomas M LinkPublished in: BMC musculoskeletal disorders (2024)
Effusion-synovitis progression was slowed by weight loss and decrease in local subcutaneous fat. Hoffa-synovitis characterized by fluid in the infrapatellar fat pad increased at the same time, suggesting a decreasing fat pad rather than active synovitis. Decrease in local subcutaneous fat partially mediated the systemic effect of weight loss on synovitis.
Keyphrases
- weight loss
- adipose tissue
- bariatric surgery
- fatty acid
- roux en y gastric bypass
- rheumatoid arthritis
- knee osteoarthritis
- type diabetes
- machine learning
- depressive symptoms
- physical activity
- electronic health record
- quality improvement
- obese patients
- glycemic control
- deep learning
- drug induced
- anterior cruciate ligament