DEC1 is required for anti-apoptotic activity of gastric cancer cells under hypoxia by promoting Survivin expression.

Yanfei JiaRui HuPing LiYan ZhengYunshan WangXiaoli Ma

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2017)

DEC1 acts as an anti-apoptotic regulator in GC cells under hypoxia by promoting Survivin expression. Our study demonstrates the critical role of the DEC1 in oncogenesis and highlights a novel role for DEC1 in the regulation of cell apoptosis in GC.

Keyphrases

poor prognosis
cell death
cell cycle arrest
induced apoptosis
endothelial cells
binding protein
anti inflammatory
cell proliferation
transcription factor
endoplasmic reticulum stress
oxidative stress
gas chromatography
signaling pathway
mass spectrometry
tandem mass spectrometry