Surface Bandgap Engineering of Nanostructured Implants for Rapid Photothermal Ion Therapy of Bone Defects.
Yang XueLan ZhangFuwei LiuYiwei ZhaoJianhong ZhouYan HouHan BaoLiang KongFei MaYong HanPublished in: Advanced healthcare materials (2022)
Bone defects are seriously threatening the health of orthopedics patients and it is difficult for implants to accelerate bone regeneration without using bone growth factors. Herein, a fast photothermal ion therapeutic strategy is developed based on the bandgap engineering of nanostructured TiO 2 through (Si/P)-dual elemental doping by micro-arc oxidation treatment of titanium implants. The (Si/P)-dual doping can tune the surface bandgap structure of TiO 2 by decreasing bandgap and broadening valence band simultaneously, which is confirmed by density functional theory calculations. It not only endows the implants with a mildly photothermal effect under near-infrared (NIR) light irradiation, but also creates an (Si/P) ion-rich microenvironment around the implants. This photothermal ion microenvironment can tune the behaviors of osteoblasts by promoting p38/Smad and ERK signaling pathways of osteoblasts, thus significantly upregulating the expression of osteogenesis genes by the synergistic action of mild photothermal stimulation and increased release of Si/P ions. The in vivo results are also in good agreement with in vitro tests, i.e., under NIR light irradiation, the photothermally responsive TiO 2 enhances the bone formation and osteointegration with implants. Therefore, this kind of photothermal ion strategy is a promising remote and noninvasive therapeutic mode for promoting bone regeneration of Ti implants.
Keyphrases
- bone regeneration
- photodynamic therapy
- cancer therapy
- soft tissue
- drug release
- density functional theory
- drug delivery
- signaling pathway
- bone mineral density
- stem cells
- end stage renal disease
- quantum dots
- room temperature
- healthcare
- chronic kidney disease
- public health
- poor prognosis
- gene expression
- fluorescence imaging
- body composition
- pi k akt
- oxidative stress
- postmenopausal women
- cell proliferation
- bone marrow
- endoplasmic reticulum stress
- transforming growth factor
- mesenchymal stem cells
- dna methylation
- genome wide identification
- cell therapy