SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in mice.

Yousef M O AlhammadSrivatsan ParthasarathyRoshan GhimireJoseph J O'ConnorCatherine M KerrJessica J PfannenstielDebarati ChandaCaden A MillerRobert L UncklessSonia ZunigaLuis Enjuanes Sunil S More Rudragouda Channappanavar Anthony R Fehr

Published in: bioRxiv : the preprint server for biology (2023)

, and does not cause significant disease in mice. These results will provide a roadmap for testing Mac1 inhibitors, help identify Mac1 functions, and open additional avenues for coronavirus therapies.

Keyphrases

sars cov
high fat diet induced
respiratory syndrome coronavirus
minimally invasive
dendritic cells
immune response
adipose tissue