Genomic Microsatellite Signatures Identify Germline Mismatch Repair Deficiency and Risk of Cancer Onset.
Jiil ChungLogine NegmVanessa BianchiLucie StengsAnirban DasZhihui Amy LiuSumedha SudhamanMelyssa AronsonLedia BrungaMelissa EdwardsVictoria J ForsterMartin KomosaScott DavidsonJodi LeesPatrick TombocDavid SamuelRoula FarahAnne BendelJeffrey KnipsteinKami Wolfe SchneiderAgnes ReschkeShayna ZelcerAlexandra ZorziRobert R McWilliamsWilliam D FoulkesRaymond BedgoodLindsay L PetersonSara RhodeAn Van DammeIsabelle ScheersSharon GardnerGabriel RobbinsMagimairajan Issai VananM Stephen MeynRebecca C AuerBrandie HealdCarol BurkeAnita VillaniDavid MalkinEric BouffetAnnie HuangMichael D TaylorCarol DurnoAdam ShlienCynthia HawkinsGad GetzYosef E MaruvkaUri Taborinull nullPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2022)
LOGIC was a robust tool for the diagnosis of MMRD in multiple cancer types and in normal tissues. LOGIC may inform therapeutic cancer decisions, provide rapid diagnosis of germline MMRD, and support tailored surveillance for individuals with CMMRD.