Absent in melanoma 2 regulates tumor cell proliferation in glioblastoma multiforme.

P A ChenG ShrivastavaE F BalcomB A McKenzieJ FernandesW G BrantonB M WheatleyK PetrukF K H van LandeghemChristopher Power

Published in: Journal of neuro-oncology (2019)

GBM tumors express a distinct profile of inflammasome-associated genes in a tumor-specific manner. AIM2 expression in tumor cells suppressed cell proliferation while also conferring increased susceptibility to contemporary GBM therapy.

Keyphrases

cell proliferation
cell cycle
poor prognosis
genome wide
pi k akt
stem cells
gene expression
mesenchymal stem cells
transcription factor
genome wide identification