Clinical validation of the novel HDAC6 radiotracer [18F]EKZ-001 in the human brain.
Michel KooleDonatienne Van WeehaegheKim SerdonsMarissa HerbotsChristopher J CawthorneSofie CelenFrederick A SchroederJacob M HookerGuy BormansJan de HoonJanice E KranzKoen Van LaereTonya M GilbertPublished in: European journal of nuclear medicine and molecular imaging (2020)
[18F]EKZ-001 is safe and appropriate for quantifying HDAC6 expression in the human brain with Logan graphical analysis as the preferred quantitative approach. Males showed higher HDAC6 expression across the brain compared to females.