CRISPR-mediated gene knockout reveals nicotinic acetylcholine receptor (nAChR) subunit α6 as a target of spinosyns in Helicoverpa armigera.

Jing WangHuanhuan MaYayun ZuoYihua YangYi-Dong Wu

Published in: Pest management science (2020)

Our results provide in vivo functional evidence for Haα6 as a target of spinosyns in H. armigera, and little or no role of Haα7 in mediating toxicity of spinosyns. The results are valuable to the development of resistance monitoring and management methods for spinosyn resistance in H. armigera. © 2020 Society of Chemical Industry.

Keyphrases

genome wide
crispr cas
oxidative stress
copy number
genome editing
gene expression
dna methylation
transcription factor
binding protein