Adipocytolytic Polymer Nanoparticles for Localized Fat Reduction.
Young Kyoung HanEun Ju JeongYerang SeoIn Young LeeSuim ChoiHyewon LeeChoonggu KimTaiyoun RhimKuen-Yong LeePublished in: ACS nano (2022)
The demand for body fat reduction is increasing. However, conventional lipolytic approaches fail to control adipose tissue reduction and cause severe side effects in adjacent nonadipose tissues. A strategy to specifically reduce subcutaneous fat using adipocytolytic polymer nanoparticles in a minimally invasive manner is reported here. The polymer nanoparticles are designed to generate carbon dioxide gas when selectively absorbed by adipocytes. The carbon dioxide gas generated within late endosomes/lysosomes induces adipocytolysis, thereby reducing the number of cells. Localized injection of the adipocytolytic nanoparticles substantially reduces subcutaneous fat in a high-fat diet-induced obese mouse model, without significant changes in hematological or serum biochemical parameters. The adipocytolytic efficacy of the nanoparticles is also evaluated in a porcine model. This strategy addresses the need to develop safe and effective adipocytolytic agents using functional polymer nanoparticles.
Keyphrases
- adipose tissue
- carbon dioxide
- insulin resistance
- minimally invasive
- mouse model
- high fat diet induced
- high fat diet
- gene expression
- metabolic syndrome
- induced apoptosis
- type diabetes
- walled carbon nanotubes
- fatty acid
- room temperature
- cell proliferation
- weight loss
- cell death
- cell cycle arrest
- robot assisted
- ionic liquid