Lipids and insulin regulate mitochondrial-derived peptide (MOTS-c) in PCOS and healthy subjects.

Manjunath RamanjaneyaJayakumar JerobinIlham BettahiMilin BensilaMyint AyeKodappully Sivaraman SiveenThozhukat SathyapalanMonica SkarulisAbdul-Badi Abou-SamraStephen L Atkin

Published in: Clinical endocrinology (2019)

In conclusion, this is the first study to show increased lipid enhanced circulating MOTS-c whilst insulin attenuated the MOTS-c response in human. Further, eight weeks of moderate exercise training did not show any changes in circulating MOTS-c levels in healthy controls and in women with PCOS.

Keyphrases

type diabetes
polycystic ovary syndrome
endothelial cells
glycemic control
fatty acid
metabolic syndrome
insulin resistance