Lipids and insulin regulate mitochondrial-derived peptide (MOTS-c) in PCOS and healthy subjects.
Manjunath RamanjaneyaJayakumar JerobinIlham BettahiMilin BensilaMyint AyeKodappully Sivaraman SiveenThozhukat SathyapalanMonica SkarulisAbdul-Badi Abou-SamraStephen L AtkinPublished in: Clinical endocrinology (2019)
In conclusion, this is the first study to show increased lipid enhanced circulating MOTS-c whilst insulin attenuated the MOTS-c response in human. Further, eight weeks of moderate exercise training did not show any changes in circulating MOTS-c levels in healthy controls and in women with PCOS.