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Lipids and insulin regulate mitochondrial-derived peptide (MOTS-c) in PCOS and healthy subjects.

Manjunath RamanjaneyaJayakumar JerobinIlham BettahiMilin BensilaMyint AyeKodappully Sivaraman SiveenThozhukat SathyapalanMonica SkarulisAbdul-Badi Abou-SamraStephen L Atkin
Published in: Clinical endocrinology (2019)
In conclusion, this is the first study to show increased lipid enhanced circulating MOTS-c whilst insulin attenuated the MOTS-c response in human. Further, eight weeks of moderate exercise training did not show any changes in circulating MOTS-c levels in healthy controls and in women with PCOS.
Keyphrases
  • type diabetes
  • polycystic ovary syndrome
  • endothelial cells
  • glycemic control
  • fatty acid
  • metabolic syndrome
  • insulin resistance