New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.
Yingchang LuFelix R DayStefan GustafssonMartin L BuchkovichJianbo NaVeronique BatailleDiana L CousminerZari DastaniAlexander W DrongTõnu EskoDavid M EvansMario FalchiMary F FeitosaTeresa FerreiraÅsa K HedmanRobin HaringPirro G HysiMark M IlesAnne E JusticeStavroula KanoniVasiliki LagouRui LiXin LiAdam LockeChen LuReedik MägiJohn R B PerryTune H PersQibin QiMarianna SannaEllen M SchmidtWilliam R ScottDmitry ShunginAlexander TeumerAnna A E VinkhuyzenRyan W WalkerHarm-Jan WestraMingfeng ZhangWeihua ZhangJing Hua ZhaoZhihong ZhuUzma AfzalTarunveer Singh AhluwaliaStephan J L BakkerClaire BellisAmélie BonnefondKatja BorodulinAron S BuchmanTommy CederholmAudrey C ChohHyung Jin ChoiJoanne E CurranLisette C P G M de GrootPhilip L De JagerRosalie A M Dhonukshe-RuttenAnke W EnnemanElodie EuryDaniel S EvansTom ForsenNele FriedrichFrédéric FumeronMelissa E GarciaSimone GärtnerBok-Ghee HanAki S HavulinnaCaroline HaywardDena HernandezHans HillegeTill IttermannJack W KentIvana KolcicTiina LaatikainenJari LahtiIrene Mateo LeachChristine G LeeJong-Young LeeTian LiuYoufang LiuStéphane LobbensMarie LohLeo-Pekka LyytikäinenCarolina Medina-GomezKarl MichaëlssonMike A NallsCarrie M NielsonLaticia OozageerLaura PascoeLavinia PaternosterOzren PolašekSamuli RipattiMark A SarzynskiChan Soo ShinNina Smolej NarančićDominik SpiraPriya SrikanthElisabeth Steinhagen-ThiessenYun Ju SungKarin M A SwartLeena TaittonenToshiko TanakaEmmi TikkanenNathalie van der VeldeNatasja M van SchoorNiek VerweijAlan F WrightLei YuJoseph M ZmudaNiina EklundTerrence ForresterNiels GrarupAnne U JacksonKati KristianssonTeemu KuulasmaaJohanna KuusistoPeter LichtnerJian'an LuanAnubha MahajanSatu MännistöCameron D PalmerJanina S RiedRobert A ScottAlena StancákováPeter J WagnerAyse DemirkanAngela DöringVilmundur GudnasonDouglas P KielBrigitte KühnelMassimo ManginoBarbara McknightCristina MenniJeffrey R O'ConnellBen A OostraAlan R ShuldinerKijoung SongLiesbeth VandenputCornelia M van DuijnPeter VollenweiderCharles C WhiteMichael BoehnkeYvonne BoettcherRichard S CooperNita G ForouhiChristian GiegerHarald GrallertAroon HingoraniTorben JørgensenPekka JousilahtiMika KivimakiMeena KumariMarkku LaaksoClaudia LangenbergAllan LinnebergAmy LukeColin A MckenzieAarno PalotieOluf PedersenAnnette PetersKonstantin StrauchBamidele O TayoNicholas J WarehamDavid A BennettLars BertramJohn BlangeroMatthias BlüherClaude BouchardHarry CampbellNam H ChoSteven R CummingsStefan A CzerwinskiIlja DemuthRahel EckardtJohan G ErikssonLuigi FerrucciOscar H FrancoPhilippe FroguelRon T GansevoortTorben HansenTamara B HarrisNicholas HastieMarkku HeliövaaraAlbert HofmanJoanne M JordanAntti JulaMika KähönenEero KajantiePaul B KnektSeppo KoskinenPeter KovacsTerho LehtimäkiLars LindYongmei LiuEric S OrwollClive OsmondMarkus PerolaLouis PérusseOlli T RaitakariTuomo RankinenD C RaoTreva K RiceFernando RivadeneiraIgor RudanVeikko SalomaaThorkild I A SørensenMichael StumvollAnke TönjesBradford TowneGregory J TranahAngelo TremblayAndré G UitterlindenPim van der HarstErkki VartiainenJorma S ViikariVeronique VitartMarie-Claude VohlHenry VölzkeMark WalkerHenri WallaschofskiSarah WildJames F WilsonLoïc YengoD Timothy BishopIngrid B BoreckiJohn C ChambersL Adrienne CupplesAbbas DehghanPanos DeloukasGhazaleh FatemifarCaroline FoxTerrence S FureyLude FrankeJiali HanDavid J HunterJuha KarjalainenFredrik KarpeRobert C KaplanJaspal S KoonerMark I McCarthyJoanne M MurabitoAndrew P MorrisJulia A N BishopKari E NorthClaes OhlssonKen K OngInga ProkopenkoJ Brent RichardsEric E SchadtTim D SpectorElisabeth WidénCristen J WillerJian YangErik IngelssonKaren L MohlkeJoel N HirschhornJohn Andrew PospisilikM Carola ZillikensCecilia LindgrenTuomas Oskari KilpeläinenRuth J F LoosPublished in: Nature communications (2016)
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.