A role for RASSF1A in tunneling nanotube formation between cells through GEFH1/Rab11 pathway control.

Fatéméh DuboisBastien Jean-JacquesHélène RobergeMagalie BénardLudovic GalasDamien SchapmanNicolas ElieDidier GouxMaureen KellerElodie MailleEmmanuel BergotGérard ZalcmanGuénaelle Levallet

Published in: Cell communication and signaling : CCS (2018)

This finding suggests for the first time that loss of RASSF1A expression could be a potential biomarker for TNTs formation, such TNTs facilitating intercellular communication favoring multistep progression of bronchial epithelial cells toward overt malignancy.

Keyphrases

induced apoptosis
poor prognosis
cell cycle arrest
endoplasmic reticulum stress
oxidative stress
cell death