The gut microbiome in intravenous immunoglobulin-treated chronic inflammatory demyelinating polyneuropathy.
Martin K R SvačinaAlina Sprenger-SvačinaAnastasia TsakmaklisAlina M RübInes KleinHauke WüstenbergGereon R FinkHelmar Christoph LehmannMaria J G T VehreschildFedja FarowskiPublished in: European journal of neurology (2023)
The gut microbiome in IVIg-treated CIDP shows distinct features, with increased bacterial diversity and enrichment of short-chain fatty acid producing Firmicutes. IVIg had no short-term impact on the gut microbiome in CIDP patients. As the main limitation of this exploratory pilot study was small cohort size, future studies also including therapy-naïve patients are warranted to verify our findings and to explore the impact of long-term IVIg treatment on the gut microbiome in CIDP.