Concordance of PD-1 and PD-L1 (B7-H1) in paired primary and metastatic clear cell renal cell carcinoma.
Jeanette E Eckel-PassowThai H HoDaniel J SerieJohn C ChevilleR Houston ThompsonBrian A CostelloHaidong DongEugene D KwonBradley C LeibovichAlexander S ParkerPublished in: Cancer medicine (2019)
The expression of PD-1 and PD-L1 is discordant across patient-matched ccRCC tumors, with higher expression in primary tumors. Higher PD-1 expression was associated with metastatic location and lower cancer-specific survival. If validated, these results highlight the importance of evaluating these biomarkers in metastatic tissue specifically.