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Clinical course and need for hospital admission after lithium discontinuation in patients with bipolar disorder type I or II: mirror-image study based on the LiSIE retrospective cohort.

Louise ÖhlundMichael OttMalin BergqvistSofia OjaRobert LundqvistMikael SandlundEllinor Salander RenbergUrsula Werneke
Published in: BJPsych open (2019)
The higher relapse risk in patients with BD-I/SZD suggests a higher threshold for discontinuing lithium than for patients with BD-II/other bipolar disorder. In patients with BD-II/other bipolar disorder, however, judged on the impact of discontinuation alone, lithium did not appear to prevent more severe depressive episodes requiring hospital admission.
Keyphrases
  • bipolar disorder
  • major depressive disorder
  • emergency department
  • solid state
  • healthcare
  • acute care
  • adverse drug
  • deep learning
  • cross sectional
  • machine learning
  • electronic health record