The possible role furin and furin inhibitors in endometrial adenocarcinoma: A narrative review.
Hayder M Al-KuraishyThabat J Al-MaiahyAli I Al-GareebAthanasios AlexiouMarios PapadakisHebatallah M SaadGaber El-Saber BatihaPublished in: Cancer reports (Hoboken, N.J.) (2023)
Furin is associated with the development and progression of EAC through the induction of proliferation, invasion, and metastasis of malignant cells of EAC. Furin induces ontogenesis in EAC through activation expression of ADAM17, pro-renin receptor, CD109, and TGF-β. As well, EAC-mediated inflammation promotes the expression of furin with further propagation of neoplastic growth and invasion.