The possible role furin and furin inhibitors in endometrial adenocarcinoma: A narrative review.

Hayder M Al-KuraishyThabat J Al-MaiahyAli I Al-GareebAthanasios AlexiouMarios PapadakisHebatallah M SaadGaber El-Saber Batiha

Published in: Cancer reports (Hoboken, N.J.) (2023)

Furin is associated with the development and progression of EAC through the induction of proliferation, invasion, and metastasis of malignant cells of EAC. Furin induces ontogenesis in EAC through activation expression of ADAM17, pro-renin receptor, CD109, and TGF-β. As well, EAC-mediated inflammation promotes the expression of furin with further propagation of neoplastic growth and invasion.

Keyphrases

poor prognosis
induced apoptosis
binding protein
oxidative stress
long non coding rna
cell cycle arrest
transforming growth factor
radiation therapy
locally advanced
cell death
angiotensin ii
angiotensin converting enzyme