High-throughput screening identifies histone deacetylase inhibitors that modulate GTF2I expression in 7q11.23 microduplication autism spectrum disorder patient-derived cortical neurons.
Francesca CavalloFlavia TroglioGiovanni FagàDaniele FancelliReinald ShytiSebastiano TrattaroMatteo ZanellaGiuseppe D'AgostinoJames M HughesMaria Rosaria CeraMaurizio PasiMichele GabrieleMaddalena LazzarinMarija MihailovichFrank KooyAlessandro RosaCiro MercurioMario VarasiGiuseppe TestaPublished in: Molecular autism (2020)
These results represent a unique opportunity for the development of a specific class of compounds for treating 7Dup and other forms of intellectual disability and autism.