A randomized, triple-blind, placebo-controlled clinical trial, evaluating the sesamin supplement effects on proteolytic enzymes, inflammatory markers, and clinical indices in women with rheumatoid arthritis.
Bizhan HelliMajid Mohammad ShahiKarim MowlaMohammad Taha JalaliHossein Khadem HaghighianPublished in: Phytotherapy research : PTR (2019)
Inflammation is one of the main characteristics of rheumatoid arthritis. Based on the antiinflammatory properties of sesame, this study was conducted to evaluate the sesamin supplement effects on serum levels of some proteolytic enzymes, inflammatory biomarkers, and clinical indices in women with rheumatoid arthritis. In this randomized, triple-blind, placebo-controlled clinical trial, 44 patients were randomly divided in intervention and control groups. Patients received 200-mg/day sesamin supplement or placebo in the intervention and control group for 6 weeks. Serum levels of proteolytic enzymes (hyaluronidase, aggrecanase, and matrix metalloproteinases-3) and inflammatory biomarkers (hs-CRP, IL-1β, IL-6, TNF-α, and cyclooxygenase-2) were measured with enzyme-linked immunosorbent assay method at the beginning and end of the study. After intervention, serum levels of hyaluronidase and matrix metalloproteinases-3 decreased significantly in sesamin group. Also, serum levels of hs-CRP, TNF-α, and cyclooxygenase-2 in intervention group were significantly decreased in intervention group compared with placebo group. Sesamin supplementation also caused a significant reduction in the number of tender joints and severity of pain in these patients. According to the results, it seems that the sesamin by reducing inflammatory mediators can relieve clinical symptoms and pathological changes that caused by inflammatory impairment in patients with rheumatoid arthritis.
Keyphrases
- rheumatoid arthritis
- double blind
- placebo controlled
- end stage renal disease
- randomized controlled trial
- clinical trial
- oxidative stress
- ejection fraction
- chronic kidney disease
- phase iii
- newly diagnosed
- study protocol
- phase ii
- peritoneal dialysis
- disease activity
- systemic lupus erythematosus
- radiation therapy
- spinal cord
- spinal cord injury
- physical activity
- depressive symptoms
- pain management
- systemic sclerosis
- sleep quality
- recombinant human
- phase ii study