Adipokines at the crossroads of obesity and mesenchymal stem cell therapy.
Duc-Vinh PhamThi-Kem NguyenPil-Hoon ParkPublished in: Experimental & molecular medicine (2023)
Mesenchymal stem cell (MSC) therapy is an emerging treatment strategy to counteract metabolic syndromes, including obesity and its comorbid disorders. However, its effectiveness is challenged by various factors in the obese environment that negatively impact MSC survival and function. The identification of these detrimental factors will provide opportunities to optimize MSC therapy for the treatment of obesity and its comorbidities. Dysregulated production of adipokines, a group of cytokines and hormones derived from adipose tissue, has been postulated to play a pivotal role in the development of obesity-associated complications. Intriguingly, adipokines have also been implicated in the modulation of viability, self-renewal, proliferation, and other properties of MSC. However, the involvement of adipokine imbalance in impaired MSC functionality has not been completely understood. On the other hand, treatment of obese individuals with MSC can restore the serum adipokine profile, suggesting the bidirectionality of the adipokine-MSC relationship. In this review, we aim to discuss the current knowledge on the central role of adipokines in the crosstalk between obesity and MSC dysfunction. We also summarize recent advances in the use of MSC for the treatment of obesity-associated diseases to support the hypothesis that adipokines modulate the benefits of MSC therapy in obese patients.
Keyphrases
- weight loss
- metabolic syndrome
- insulin resistance
- adipose tissue
- type diabetes
- cell therapy
- obese patients
- bariatric surgery
- high fat diet induced
- weight gain
- healthcare
- randomized controlled trial
- mesenchymal stem cells
- stem cells
- bone marrow
- high fat diet
- signaling pathway
- oxidative stress
- gastric bypass
- body mass index
- physical activity
- replacement therapy