The Genetic Architecture of Biological Age in Nine Human Organ Systems.

Junhao Wen Ye Ella TianIoanna SkampardoniZhijian YangElizabeth MamourianFilippos AnagnostakisBingxin ZhaoArthur W TogaAndrew ZaleskeyChristos Davatzikos

Published in: medRxiv : the preprint server for health sciences (2023)

Across nine human organ systems, the genetic architectures of the biological age gap (BAG) revealed BAG-organ specificity and inter-organ crosstalk, highlighting the interconnections among multiple organ systems, chronic diseases, body weight, and lifestyle factors.

Keyphrases

body weight
endothelial cells
metabolic syndrome
genome wide
cardiovascular disease
gene expression
weight loss
pluripotent stem cells
dna methylation