Non-invasive biomarkers of disease activity and organ damage in ANCA-associated vasculitis: a systematic review.
Thomas RensonMargaret M KellyHallgrimur BenediktssonNele GrundhoeferNadia LucaPaivi MiettunenMarinka TwiltSilviu GrisaruAndrew WadeAnke BanksAurore Fifi-MahLorraine HamiwkaSusanne BenselerPublished in: RMD open (2024)
This is the first contemporary systematic review synthesising the value of non-invasive biomarkers of AAV-related disease activity and organ damage. The incorporation of individual markers in combined biomarker profiles might enhance clinical decision-making. Many unmet needs were identified; few studies involve oeosinophilic granulomatosis with polyangiitis and patients with childhood-onset AAV. Further validation of the candidate biomarkers is warranted in large prospective studies to bridge the existing knowledge gaps and apply precision health to systemic vasculitis.
Keyphrases
- disease activity
- systemic lupus erythematosus
- rheumatoid arthritis
- rheumatoid arthritis patients
- systematic review
- ankylosing spondylitis
- juvenile idiopathic arthritis
- healthcare
- decision making
- oxidative stress
- public health
- case control
- mental health
- risk assessment
- early life
- health information
- drug induced
- health promotion