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Assessing sleep-wake survival dynamics in relation to sleep quality in a placebo-controlled pharmacological intervention study with people with insomnia and healthy controls.

Lieke W A HermansMarta RegisPedro FonsecaSebastiaan OvereemTim R M LeufkensAnnemiek VermeerenMerel M van Gilst
Published in: Psychopharmacology (2020)
Impaired subjective sleep quality is associated with decreased NREM stability, together with increased stability of wake. Furthermore, we conclude that zopiclone-induced changes in SOL misperception can be largely attributed to predictable changes of sleep architecture.
Keyphrases
  • sleep quality
  • depressive symptoms
  • physical activity
  • randomized controlled trial
  • placebo controlled
  • double blind
  • study protocol
  • phase iii
  • open label