Systems biology of oxygen homeostasis.

Debangshu SamantaNanduri R PrabhakarGregg L Semenza

Published in: Wiley interdisciplinary reviews. Systems biology and medicine (2017)

Metazoan species maintain oxygen homeostasis through the activity of hypoxia-inducible factors, which are transcriptional activators that regulate the expression of hundreds of genes to match O2 supply and demand. Here, we review the involvement of hypoxia-inducible factors in the molecular physiology and pathophysiology of cellular O2 sensing, O2 delivery, O2 utilization, and systemic O2 sensing. WIREs Syst Biol Med 2017, 9:e1382. doi: 10.1002/wsbm.1382 For further resources related to this article, please visit the WIREs website.

Keyphrases

endothelial cells
poor prognosis
gene expression
genome wide
transcription factor
binding protein
single molecule
oxidative stress
drug induced
bioinformatics analysis
heat shock