High prevalence of "non-pathogenic" POLE mutation with poor prognosis in a cohort of endometrial cancer from South India.
Santhosh KuriakoseDhananjayan DhanasoorajP M ShinyS ShammyV P SonaAnupama A ManjulaAmrutha RamachandranBindu VijaykumarNayana SusanM DinesanUma V SankarKavitha RamachandranP S SreedharanPublished in: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (2024)
This study identified a unique set of POLE mutations in Indian EC patients associated with poor prognosis, which were particularly pronounced in advanced stages. Advanced stage of presentation, type of POLE mutations, and possibly ethnicity are predictors of adverse outcomes in POLE-mutated EC. The present study highlights ethnicity as a determinant of phenotypic expression of genetic change.