Liquid Biopsy in Gastrointestinal Cancers.
Aman SainiYash PershadHassan AlbadawiMalia KuoSadeer AlzubaidiSailendra NaiduM-Grace KnuttinenRahmi OkluPublished in: Diagnostics (Basel, Switzerland) (2018)
Liquid biopsy is the sampling of any biological fluid in an effort to enrich and analyze a tumor's genetic material. Peripheral blood remains the most studied liquid biopsy material, with circulating tumor cells (CTC's) and circulating tumor DNA (ctDNA) allowing the examination and longitudinal monitoring of a tumors genetic landscape. With applications in cancer screening, prognostic stratification, therapy selection and disease surveillance, liquid biopsy represents an exciting new paradigm in the field of cancer diagnostics and offers a less invasive and more comprehensive alternative to conventional tissue biopsy. Here, we examine liquid biopsies in gastrointestinal cancers, specifically colorectal, gastric, and pancreatic cancers, with an emphasis on applications in diagnostics, prognostics and therapeutics.
Keyphrases
- circulating tumor
- circulating tumor cells
- ultrasound guided
- fine needle aspiration
- cell free
- ionic liquid
- peripheral blood
- papillary thyroid
- genome wide
- squamous cell carcinoma
- squamous cell
- cross sectional
- single cell
- stem cells
- mesenchymal stem cells
- young adults
- gene expression
- lymph node metastasis
- bone marrow
- cell therapy