Novel role of mortalin in attenuating HIV-1 Tat-mediated astrogliosis.
null PriyankaRenu WadhwaRituparna ChaudhuriTapas Chandra NagPankaj SethPublished in: Journal of neuroinflammation (2020)
Overall, our data demonstrated the protective role of mortalin in combating HIV-1 Tat-mediated damage. We also showed that mortalin could degrade Tat through direct binding with HIV-1 Tat. Overexpression of mortalin in the presence of Tat could significantly reduce cytotoxic effects of Tat in astrocytes. Indirect neuronal death was also found to be rescued. Our in vitro findings were validated as we found attenuated expression of mortalin in the autopsy sections of HIV-1 patients.
Keyphrases
- antiretroviral therapy
- hiv positive
- hiv infected
- hiv testing
- human immunodeficiency virus
- hepatitis c virus
- hiv aids
- men who have sex with men
- end stage renal disease
- south africa
- poor prognosis
- ejection fraction
- newly diagnosed
- oxidative stress
- cell proliferation
- machine learning
- brain injury
- prognostic factors
- artificial intelligence
- big data
- patient reported outcomes
- cerebral ischemia
- dna binding