Increased expression of interleukin-9 in patients with allergic contact dermatitis caused by p-phenylenediamine.

Marie Baeck Anne HermanLaurence de MontjoyeEmilie HendrickxPaméla ChéouPerrine M CochezLaure Dumoutier

Published in: Contact dermatitis (2018)

We did not confirm the preclinical presence of CD8+ T cells. However, the expression of different T cell markers positively correlated with patch test reactions. IL-9 expression was strongly upregulated and directly related to patch test severity. In addition, we showed that IL-9 has an anti-inflammatory role in a mouse model of PPD contact hypersensitivity.

Keyphrases

poor prognosis
mouse model
anti inflammatory
binding protein
long non coding rna
cell therapy
drug induced