Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy.

Jiaqi YanHaixia ZouWenhui ZhouXiaowan YuanZhijun LiXiaodong MaChang LiuYonghui WangJessica M Rosenholm Wenguo Cu Xiangmeng Qu Hongbo Zhang

Published in: Biomaterials science (2022)

Herein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy. This toehold mediated strand displacement method can simultaneously achieve specific drug release and miRNA-21 silencing, resulting in the up-regulation of the expression of tumor suppressor genes PTEN and PDCD4.

Keyphrases

cancer therapy
drug delivery
drug release
poor prognosis
cell proliferation
circulating tumor
single molecule
cell free
locally advanced
stem cells
binding protein
gene expression
genome wide analysis
bone marrow
walled carbon nanotubes
circulating tumor cells