Cigarette smoke extract decreased basal and lipopolysaccharide-induced expression of MARCO via degradation of p300.

Kyoung-Hee LeeJisu WooJiyeon KimChang Hoon LeeChul-Gyu Yoo

Published in: Respirology (Carlton, Vic.) (2020)

These findings suggest that CSE decreases MARCO expression via the proteasomal degradation of p300 in macrophages, which may be in part responsible for impaired bacterial phagocytosis.

Keyphrases

lipopolysaccharide induced
poor prognosis
inflammatory response
binding protein
oxidative stress
anti inflammatory