Elevated In Vitro Kinase Activity in Peripheral Blood Mononuclear Cells of Leucine-Rich Repeat Kinase 2 G2019S Carriers: A Novel Enzyme-Linked Immunosorbent Assay-Based Method.

Katerina MelachroinouMin Suk KangChristopher LiongSushma NarayanNajah LeversNeal JoshiKatie KopilSamantha J HuttenMarco A S BaptistaShalini PadmanabhanUn Jung KangLeonidas StefanisRoy N AlcalayHardy J Rideout

Published in: Movement disorders : official journal of the Movement Disorder Society (2020)

Quantitative assays such as these described here could potentially uncover specific markers of leucine-rich repeat kinase 2 function that are predictive of disease progression, aid in patient stratification, and be a critical component of upcoming clinical trials. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyphrases

clinical trial
protein kinase
high throughput
tyrosine kinase
case report
randomized controlled trial
systematic review
high resolution
mass spectrometry
double blind
phase iii